The Landscape of Genetic Alterations Stratified Prognosis in Oriental Pancreatic Cancer Patients.

ABSTRACT:

Background

Pancreatic cancer is a life-threatening malignant disease with significant diversity among geographic regions and races leading to distinct carcinogenesis and prognosis. Previous studies mainly focused on Western patients, while the genomic landscape of Oriental patients, especially Chinese, remained less investigated.

Methods

A total of 408 pancreatic cancer patients were enrolled. A panel containing 436 cancer-related genes was used to detect genetic alterations in tumor samples.

Results

We profiled the genomic alteration landscape of pancreatic duct adenocarcinoma (PDAC), intraductal papillary mucinous neoplasm (IPMN), periampullary carcinoma (PVC), and solid-pseudopapillary tumor (SPT). Comparison with a public database revealed specific gene mutations

SUBMITTER: Guo S 

PROVIDER: S-EPMC8340855 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature