Synthetic hyperacetylation of nucleosomal histones.

ABSTRACT: We report combinations of a DMAP-based catalyst and phenyl acetate with optimal electron density as a new chemical system for high-yield, selective synthetic acetylation of histone lysine residues. The utility of this chemical system as a unique biologic tool is demonstrated by applying it to Xenopus laevis sperm chromatin.

SUBMITTER: Kajino H 

PROVIDER: S-EPMC8341002 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature