Diagnostic Accuracy of Salivary Metanephrines in Pheochromocytomas and Paragangliomas.

ABSTRACT:

Background

Measurements of plasma free metanephrines are recommended for diagnosing pheochromocytomas and paragangliomas (PPGL). Metanephrines can be detected in saliva with LC-MS/MS with sufficient analytical sensitivity and precision. Because collecting saliva is noninvasive and less cumbersome than plasma or urine sampling, we assessed the diagnostic accuracy of salivary metanephrines in diagnosing PPGL.

Methods

This 2-center study included 118 healthy participants (44 men; mean age: 33 years (range: 19--74 years)), 44 patients with PPGL, and 54 patients suspected of PPGL. Metanephrines were quantified in plasma and saliva using LC-MS/MS. Diagnostic accuracy; correlation between plasma and salivary metanephrines; and potential factors influencing salivary metanephrines, i

SUBMITTER: Eijkelenkamp K 

PROVIDER: S-EPMC8341008 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature