Cholinergic receptor nicotinic beta 3 subunit polymorphisms and smoking in male Chinese patients with schizophrenia.

ABSTRACT:

Objective

The aim of this study was to examine if cholinergic receptor nicotinic beta 3 subunit (CHRNB3) was a common genetic basis for both nicotine dependence and schizophrenia.

Methods

Two CHRNB3 promoter single nucleotide polymorphisms (SNPs) were genotyped in 773 patients with schizophrenia and 302 healthy volunteers. Associations between smoking, schizophrenia, smoking+schizophrenia and CHRNB3 were analyzed. The mRNA expression of CHRNB3 in human brains was examined, and the expression correlations between CHRNB3 and dopaminergic and GABAergic receptor genes were evaluated.

Results

The association between CHRNB3 and smoking was significant in the total sample, less significant in the smoking with schizophrenia, and sugge

SUBMITTER: Shi J 

PROVIDER: S-EPMC8341072 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature