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Chemogenomics for drug discovery: clinical molecules from open access chemical probes.

ABSTRACT: In recent years chemical probes have proved valuable tools for the validation of disease-modifying targets, facilitating investigation of target function, safety, and translation. Whilst probes and drugs often differ in their properties, there is a belief that chemical probes are useful for translational studies and can accelerate the drug discovery process by providing a starting point for small molecule drugs. This review seeks to describe clinical candidates that have been inspired by, or derived from, chemical probes, and the process behind their development. By focusing primarily on examples of probes developed by the Structural Genomics Consortium, we examine a variety of epigenetic modulators along with other classes of probe.

SUBMITTER: Quinlan RBA

PROVIDER: S-EPMC8341094 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Chemogenomics for drug discovery: clinical molecules from open access chemical probes.

Quinlan Robert B A RBA Brennan Paul E PE

RSC chemical biology 20210326 3

In recent years chemical probes have proved valuable tools for the validation of disease-modifying targets, facilitating investigation of target function, safety, and translation. Whilst probes and drugs often differ in their properties, there is a belief that chemical probes are useful for translational studies and can accelerate the drug discovery process by providing a starting point for small molecule drugs. This review seeks to describe clinical candidates that have been inspired by, or der ...[more]

PMID: 34458810

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