Transfusion-related immunomodulation: review of the literature and implications for pediatric critical illness.

ABSTRACT: Transfusion-related immunomodulation (TRIM) in the intensive care unit (ICU) is difficult to define and likely represents a complicated set of physiologic responses to transfusion, including both proinflammatory and immunosuppressive effects. Similarly, the immunologic response to critical illness in both adults and children is highly complex and is characterized by both acute inflammation and acquired immune suppression. How transfusion may contribute to or perpetuate these phenotypes in the ICU is poorly understood, despite the fact that transfusion is common in critically ill patients. Both hyperinflammation and severe immune suppression are associated with poor outcomes from critical illness, underscoring the need to understand potential immunologic consequences of blood product transf

SUBMITTER: Muszynski JA 

PROVIDER: S-EPMC8341144 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature