Modified internucleoside linkages for nuclease-resistant oligonucleotides.

ABSTRACT: In the past few years, several drugs derived from nucleic acids have been approved for commercialization and many more are in clinical trials. The sensitivity of these molecules to nuclease digestion in vivo implies the need to exploit resistant non-natural nucleotides. Among all the possible modifications, the one concerning the internucleoside linkage is of particular interest. Indeed minor changes to the natural phosphodiester may result in major modifications of the physico-chemical properties of nucleic acids. As this linkage is a key element of nucleic acids' chemical structures, its alteration can strongly modulate the plasma stability, binding properties, solubility, cell penetration and ultimately biological activity of nucleic acids. Over the past few decades, many researc

SUBMITTER: Clave G 

PROVIDER: S-EPMC8341215 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature