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Biosynthesis of alkyne-containing natural products.

ABSTRACT: Alkyne-containing natural products are important molecules that are widely distributed in microbes and plants. Inspired by the advantages of acetylenic products used in the fields of medicinal chemistry, organic synthesis and material science, great efforts have focused on discovering the biosynthetic enzymes and pathways for alkyne formation. Here, we summarize the biosyntheses of alkyne-containing natural products and introduce de novo biosynthetic strategies for alkyne-tagged compound production.

SUBMITTER: Li X

PROVIDER: S-EPMC8341276 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Biosynthesis of alkyne-containing natural products.

Li Xinyang X Lv Jian-Ming JM Hu Dan D Abe Ikuro I

RSC chemical biology 20201221 1

Alkyne-containing natural products are important molecules that are widely distributed in microbes and plants. Inspired by the advantages of acetylenic products used in the fields of medicinal chemistry, organic synthesis and material science, great efforts have focused on discovering the biosynthetic enzymes and pathways for alkyne formation. Here, we summarize the biosyntheses of alkyne-containing natural products and introduce <i>de novo</i> biosynthetic strategies for alkyne-tagged compound ...[more]

PMID: 34458779

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