The association of OPG polymorphisms with risk of osteoporotic fractures: A systematic review and meta-analysis.

ABSTRACT:

Background

Subjects with low bone mineral density and osteoporosis are more likely to suffer osteoporotic fractures during their lifetime. Polymorphisms in osteoprotegerin (OPG) gene are found to be associated with low bone mineral density and osteoporosis risk but their association with fracture risk is inconclusive. Here, we performed a meta-analysis to investigate the relationship between OPG polymorphisms with susceptibility to osteoporotic fractures.

Methods

Eligible studies investigating the association between common OPG polymorphisms (A164G, T245G, T950C, and G1181C) and risk of osteoporotic fracture were retrieved from PubMed, EMBASE, Web of Science, and the Cochrane Library. Odds ratio (OR) and the 95% confidence interval (CI) were calculated in the allelic, domina

SUBMITTER: Ding J 

PROVIDER: S-EPMC8341286 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature