Increased expression of Cyclin F in liver cancer predicts poor prognosis: A study based on TCGA database.

ABSTRACT:

Background

Cyclin F (CCNF) dysfunction has been implicated in various forms of cancer, offering a new avenue for understanding the pathogenic mechanisms underlying hepatocellular carcinoma (HCC). We aimed to evaluate the role of CCNF in HCC using publicly available data from The Cancer Genome Atlas (TCGA).

Method

We used TCGA data and Gene Expression Omnibus (GEO) data to analyze the differential expression of CCNF between tumor and adjacent tissues and the relationship between CCNF and clinical characteristics. We compared prognosis of patients with HCC with high and low CCNF expression and constructed receiver operating characteristic (ROC) curves. In addition, we also explored the types of gene mutations in relevant groups and conducted Gene Set Enrichment Analysis (GSEA)

SUBMITTER: Zelong Y 

PROVIDER: S-EPMC8341327 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature