Rational design of a stapled JAZ9 peptide inhibiting protein-protein interaction of a plant transcription factor.

ABSTRACT: We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in Arabidopsis thaliana. It is proposed as a novel chemical tool for the analysis of MYC related jasmoante signaling.

SUBMITTER: Suzuki K 

PROVIDER: S-EPMC8341433 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature