Hyaluronan (HA)-inspired glycopolymers as molecular tools for studying HA functions.

ABSTRACT: Hyaluronic acid (HA), the only non-sulphated glycosaminoglycan, serves numerous structural and biological functions in the human body, from providing viscoelasticity in tissues to creating hydrated environments for cell migration and proliferation. HA is also involved in the regulation of morphogenesis, inflammation and tumorigenesis through interactions with specific HA-binding proteins. Whilst the physicochemical and biological properties of HA have been widely studied for decades, the exact mechanisms by which HA exerts its multiple functions are not completely understood. Glycopolymers offer a simple and precise synthetic platform for the preparation of glycan analogues, being an alternative to the demanding synthetic chemical glycosylation. A library of homo, statistical and alternati

SUBMITTER: Collis DWP 

PROVIDER: S-EPMC8341579 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature