PMGF505-7R determines pathogenicity of African swine fever virus infection by inhibiting IL-1β and type I IFN production.

ABSTRACT: Inflammatory factors and type I interferons (IFNs) are key components of host antiviral innate immune responses, which can be released from the pathogen-infected macrophages. African swine fever virus (ASFV) has developed various strategies to evade host antiviral innate immune responses, including alteration of inflammatory responses and IFNs production. However, the molecular mechanism underlying inhibition of inflammatory responses and IFNs production by ASFV-encoded proteins has not been fully understood. Here we report that ASFV infection only induced low levels of IL-1β and type I IFNs in porcine alveolar macrophages (PAMs), even in the presence of strong inducers such as LPS and poly(dA:dT). Through further exploration, we found that several members of the multigene family 360 (MGF3

SUBMITTER: Li J 

PROVIDER: S-EPMC8341718 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature