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The chemical biology of IL-12 production via the non-canonical NFkB pathway.

ABSTRACT: Interleukin-12 (IL-12) has emerged as an attractive cytokine for cancer therapy because it has direct anti-cancer effects and additionally plays a critical role in enhancing checkpoint inhibitors. Given these multiple modes of actions, identifying means to pharmacologically induce IL-12 production in the tumor microenvironment has become important. In this review, we highlight therapeutics that promote IL-12 induction in tumor-associated myeloid cells through the non-canonical NFkB pathway. We discuss existing clinical trials and briefly examine the additional pathway targets that warrant further exploration for drug discovery.

SUBMITTER: Koch PD

PROVIDER: S-EPMC8341911 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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The chemical biology of IL-12 production <i>via</i> the non-canonical NFkB pathway.

Koch Peter D PD Pittet Mikael J MJ Weissleder Ralph R

RSC chemical biology 20200722 4

Interleukin-12 (IL-12) has emerged as an attractive cytokine for cancer therapy because it has direct anti-cancer effects and additionally plays a critical role in enhancing checkpoint inhibitors. Given these multiple modes of actions, identifying means to pharmacologically induce IL-12 production in the tumor microenvironment has become important. In this review, we highlight therapeutics that promote IL-12 induction in tumor-associated myeloid cells through the non-canonical NFkB pathway. We d ...[more]

PMID: 34458756

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