Aquaporin-driven hydrogen peroxide transport: a case of molecular mimicry?

ABSTRACT: Aquaporins (AQPs) are membrane proteins that have evolved to control cellular water uptake and efflux, and as such are amongst the most ancient biological "devices" in cellular organisms. Recently, using metadynamics, we have shown that water nanoconfinement within aquaporin channels results into bidirectional water movement along single file chains, extending previous investigations. Here, the elusive mechanisms of H₂O₂ facilitated transport by the human 'peroxiporin' AQP3 has been unravelled via a combination of atomistic simulations, showing that while hydrogen peroxide is able to mimic water during AQP3 permeation, this comes at a certain energy expense due to the required conformational changes within the channel. Furthermore, the intrinsic water dynamics

SUBMITTER: Wragg D 

PROVIDER: S-EPMC8341912 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature