Genomic analysis of host gene responses to cerebral Plasmodium falciparum malaria.

ABSTRACT:

Introduction

A vaccine for malaria is urgently required but no vaccine has yet shown satisfactory protective efficacy especially for Plasmodium falciparum. P. falciparum infection can progress to cerebral malaria (CM), a neurological syndrome with exceedingly high mortality. Designing effective P. falciparum vaccines require more understanding of the protective immune response while the host immune response to CM and the mechanisms are still elusive. Here, we aim to identify host gene responses to CM and host gene networks associated with CM pathogenesis.

Methods

An innovative genomic analysis strategy, the weighted gene coexpression network analysis (WGCNA) combined with differential gene expression analysis, was used in this study. Data for analysis contain 93 whole blood

SUBMITTER: Li K 

PROVIDER: S-EPMC8342194 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature