Novel Protocols for Scalable Production of High Quality Purified Small Extracellular Vesicles from Bovine Milk.

ABSTRACT: Extracellular Vesicles (EVs) are cell-secreted nanovesicles that have unique potential for encapsulating and targeting "difficult-to-drug" therapeutic cargos. Milk provides an enriched source of EVs, and of particular interest to the drug delivery field, small EVs. Small EVs are distinguished from large EVs by membrane components, biogenesis mechanism and downstream functionality - in particular, small EVs are primarily composed of exosomes, which show high stability in vivo and naturally function in the targeted delivery of biological materials to cells. Moreover, bovine milk is abundantly produced by the dairy industry, widely consumed, and generally well tolerated by humans. Importantly, there is evidence that milk exosomes and small EVs are efficiently taken up into the circulat

SUBMITTER: Marsh SR 

PROVIDER: S-EPMC8342262 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature