Real-World Healthcare Resource Utilization (HRU) and Costs of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Receiving Eculizumab in a US Population.

ABSTRACT:

Introduction

To evaluate the economic burden and treatment patterns of patients with paroxysmal nocturnal hemoglobinuria (PNH) treated with eculizumab, a C5 inhibitor, who were defined as blood transfusion-dependent (TD) versus blood transfusion-free (TF) in the US population.

Methods

Patients aged at least 12 years with at least two claims for eculizumab infusion (first claim was the index date) were identified from the IBM^® MarketScan^® Research Databases (April 1, 2014-September 30, 2019). The overall PNH eculizumab user cohort was stratified into the TD cohort (i.e., at least one claim for blood transfusion within 6 months following any eculizumab infusion, including on the infusion date) or the TF cohort (i.e., all non-TD patients). Treatment patter

SUBMITTER: Cheng WY 

PROVIDER: S-EPMC8342328 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature