Restricted differentiative capacity of Wt1-expressing peritoneal mesothelium in postnatal and adult mice.

ABSTRACT: Previously, genetic lineage tracing based on the mesothelial marker Wt1, appeared to show that peritoneal mesothelial cells have a range of differentiative capacities and are the direct progenitors of vascular smooth muscle in the intestine. However, it was not clear whether this was a temporally limited process or continued throughout postnatal life. Here, using a conditional Wt1-based genetic lineage tracing approach, we demonstrate that the postnatal and adult peritoneum covering intestine, mesentery and body wall only maintained itself and failed to contribute to other visceral tissues. Pulse-chase experiments of up to 6 months revealed that Wt1-expressing cells remained confined to the peritoneum and failed to differentiate into cellular components of blood vessels or other tissues un

SUBMITTER: Wilm TP 

PROVIDER: S-EPMC8342433 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature