An extended reconstruction of human gut microbiota metabolism of dietary compounds.

ABSTRACT: Understanding how diet and gut microbiota interact in the context of human health is a key question in personalized nutrition. Genome-scale metabolic networks and constraint-based modeling approaches are promising to systematically address this complex problem. However, when applied to nutritional questions, a major issue in existing reconstructions is the limited information about compounds in the diet that are metabolized by the gut microbiota. Here, we present AGREDA, an extended reconstruction of diet metabolism in the human gut microbiota. AGREDA adds the degradation pathways of 209 compounds present in the human diet, mainly phenolic compounds, a family of metabolites highly relevant for human health and nutrition. We show that AGREDA outperforms existing reconstructions in predictin

SUBMITTER: Blasco T 

PROVIDER: S-EPMC8342455 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature