Whole blood gene expression within days after total-body irradiation predicts long term survival in Gottingen minipigs.

ABSTRACT: Gottingen minipigs mirror the physiological radiation response observed in humans and hence make an ideal candidate model for studying radiation biodosimetry for both limited-sized and mass casualty incidents. We examined the whole blood gene expression profiles starting one day after total-body irradiation with increasing doses of gamma-rays. The minipigs were monitored for up to 45 days or time to euthanasia necessitated by radiation effects. We successfully identified dose- and time-agnostic (over a 1-7 day period after radiation), survival-predictive gene expression signatures derived using machine-learning algorithms with high sensitivity and specificity. These survival-predictive signatures fare better than an optimally performing dose-differentiating signature or blood cellular prof

SUBMITTER: Chopra S 

PROVIDER: S-EPMC8342483 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature