TEMOBIC: Phase II Trial of Neoadjuvant Chemotherapy for Unresectable Anaplastic Gliomas: An ANOCEF Study.

ABSTRACT:

Lessons learned

Treatment with temozolomide and BCNU was associated with substantial response and survival rates for patients with unresectable anaplastic glioma, suggesting potential therapeutic alternative for these patients. The optimal treatment for unresectable large anaplastic gliomas remains debated.

Background

The optimal treatment for unresectable large anaplastic gliomas remains debated.

Methods

Adult patients with histologically proven unresectable anaplastic oligodendroglioma or mixed gliomas (World Health Organization [WHO] 2007) were eligible. Treatment consisted of BCNU (150 mg/m² ) and temozolomide (110 mg/m² for 5 days) every 6 weeks for six cycles before radiotherapy.

Results

Between December 2005 and December 2009, 55 pa

SUBMITTER: Tabouret E 

PROVIDER: S-EPMC8342578 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature