Publication Bias in Gastrointestinal Oncology Trials Performed over the Past Decade.

ABSTRACT:

Background

Randomized controlled trials (RCTs) are the gold standard for evidence-based practice, but their development and implementation is resource intensive. We aimed to describe modern RCTs in gastrointestinal (GI) cancer and identify predictors of successful accrual and publication.

Materials and methods

ClinicalTrials.gov was queried for phase III GI cancer RCTs opened between 2010 and 2019 and divided into two cohorts: past and recruiting. Past trials were analyzed for predictors of successful accrual and the subset with ≥3 years follow-up were analyzed for predictors of publication. Univariate and multivariable (MVA) logistic regression were used to identify covariates associated with complete accrual and publication status.

Results

A total of 533 GI RCTs wer

SUBMITTER: Peters GW 

PROVIDER: S-EPMC8342580 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature