Comparison of Genomic Characterization in Upper Tract Urothelial Carcinoma and Urothelial Carcinoma of the Bladder.

ABSTRACT:

Background

Different genomic characterization in urothelial carcinoma (UC) by site of origin may imply contrasting therapeutic opportunities and pathogenetic mechanisms. The aim of this study was to investigate whether differences between upper tract UC (UTUC) and UC of the bladder (UCB) result from intrinsic biological diversity.

Materials and methods

We prospectively sequenced 118 tumors and matched blood DNA from Chinese patients with UC using next-generation sequencing techniques, including 45 UTUC and 73 UCB. Two hundred twenty-six patients with UTUC and 350 patients with UCB for The Cancer Genome Atlas were acquired from the cbioportal.

Results

There were marked disparities in the mutational landscape for UC according to race and site of origin. Signature 22 for

SUBMITTER: Yang K 

PROVIDER: S-EPMC8342585 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature