Efficacy of Neratinib Plus Capecitabine in the Subgroup of Patients with Central Nervous System Involvement from the NALA Trial.

ABSTRACT:

Background

Neratinib has efficacy in central nervous system (CNS) metastases from HER2-positive metastatic breast cancer (MBC). We report outcomes among patients with CNS metastases at baseline from the phase III NALA trial of neratinib plus capecitabine (N + C) versus lapatinib plus capecitabine (L + C).

Materials and methods

NALA was a randomized, active-controlled trial in patients who received two or more previous HER2-directed regimens for HER2-positive MBC. Patients with asymptomatic/stable brain metastases (treated or untreated) were eligible. Patients were assigned to N + C (neratinib 240 mg per day, capecitabine 750 mg/m² twice daily) or L + C (lapatinib 1,250 mg per day, capecitabine 1,000 mg/m² twice daily) orally. Independently adjudicated p

SUBMITTER: Hurvitz SA 

PROVIDER: S-EPMC8342591 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature