Fluorescence/photoacoustic imaging-guided nanomaterials for highly efficient cancer theragnostic agent.

ABSTRACT: Imaging modalities combined with a multimodal nanocomposite contrast agent hold great potential for significant contributions in the biomedical field. Among modern imaging techniques, photoacoustic (PA) and fluorescence (FL) imaging gained much attention due to their non-invasive feature and the mutually supportive characteristic in terms of spatial resolution, penetration depth, imaging sensitivity, and speed. In this present study, we synthesized IR783 conjugated chitosan-polypyrrole nanocomposites (IR-CS-PPy NCs) as a theragnostic agent used for FL/PA dual-modal imaging. A customized FL and photoacoustic imaging system was constructed to perform required imaging experiments and create high-contrast images. The proposed nanocomposites were confirmed to have great biosafety, essentially a

SUBMITTER: Doan VHM 

PROVIDER: S-EPMC8342712 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature