Assessment of causal effects of physical activity on neurodegenerative diseases: A Mendelian randomization study.

ABSTRACT:

Background

Physical activity has been hypothesized to play a protective role in neurodegenerative diseases. However, effect estimates previously derived from observational studies were prone to confounding or reverse causation.

Methods

We performed a two-sample Mendelian randomization (MR) analysis to explore the causal association of accelerometer-measured physical activity with 3 common neurodegenerative diseases: Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). We selected genetic instrumental variants reaching genome-wide significance (p < 5 × 10^-8) from 2 largest meta-analyses of about 91,100 UK Biobank participants. Summary statistics for AD, PD, and ALS were retrieved from the up-to-date studies in European ancest

SUBMITTER: Wu PF 

PROVIDER: S-EPMC8343066 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature