Porphyromonas somerae Invasion of Endometrial Cancer Cells.

ABSTRACT: Recent evidence suggests an association between endometrial cancer and the understudied bacterial species Porphyromonas somerae. This association was demonstrated in previous work that indicated a significantly enriched abundance of P. somerae in the uterine microbiome of endometrial cancer patients. Given the known associations of the Porphyromonas genus and oral cancer, we hypothesized that P. somerae may play a similar pathogenic role in endometrial cancer via intracellular activity. Before testing our hypothesis, we first characterized P. somerae biology, as current background data is limited. These novel characterizations include growth curves in liquid medium and susceptibility tests to antibiotics. We tested our hypothesis by examining growth chang

SUBMITTER: Crooks TA 

PROVIDER: S-EPMC8343132 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature