Are COL4A1 and COL4A2 gene polymorphisms associated with cerebral palsy?

ABSTRACT:

Objectives

This study aims to investigate the association of COL4A1 and COL4A2 gene polymorphisms with susceptibility to risk of developing cerebral palsy (CP) and severity of CP.

Patients and methods

Between December 2016 and June 2017, a total of 176 patients with CP (101 males, 75 females; mean age 71.8±37.9 months; range, 24 to 184 months) and age-, sex-, and ethnically-matched 178 (90 males, 88 females; mean age 69.3±55.2 months; range, 24 to 214 months) controls were included. Two polymorphisms of COL4A1 (rs1961495) and COL4A2 (rs9521733) genes were typed from genomic deoxyribonucleic acid. Genotype distributions and allelic frequencies were compared between the patient and control groups. Gross Motor Function Classification System, the use of medical drugs, type of in

SUBMITTER: Guvener O 

PROVIDER: S-EPMC8343154 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature