Multi-Omic Analyses of the m⁵C Regulator ALYREF Reveal Its Essential Roles in Hepatocellular Carcinoma.

ABSTRACT: The ALYREF protein acts as a crucial epigenetic regulator in several cancers. However, the specific expression levels and functional roles of ALYREF in cancers are largely unknown, including for hepatocellular carcinoma (HCC). In a pan-cancer tissue analysis that included HCC, we assessed the expression of ALYREF compared to normal tissues using The Cancer Genome Atlas database. Associations between ALYREF gene expression and the clinical characteristics of HCC patient samples were assessed using the UALCAN database. Kaplan-Meier plots were performed to assess HCC patient prognosis, and the TIMER database was used to explore associations between ALYREF expression and immune-cell infiltrations. The same methods were used to assess eIF4A3 expression in HCC patient samples. In addition, ALYRE

SUBMITTER: Xue C 

PROVIDER: S-EPMC8343179 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature