Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series.

ABSTRACT:

Background

Influenza virus infection is an important cause of under-five mortality. Maternal vaccination protects children younger than 3 months of age from influenza infection. However, it is unknown to what extent paediatric influenza-related mortality may be prevented by a maternal vaccine since global age-stratified mortality data are lacking.

Methods

We invited clinicians and researchers to share clinical and demographic characteristics from children younger than 5 years who died with laboratory-confirmed influenza infection between January 1, 1995 and March 31, 2020. We evaluated the potential impact of maternal vaccination by estimating the number of children younger than 3 months with in-hospital influenza-related death using published global mortality estimates.

SUBMITTER: Lowensteyn YN 

PROVIDER: S-EPMC8343247 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature