TRAIL-coated leukocytes to kill circulating tumor cells in the flowing blood from prostate cancer patients.

ABSTRACT:

Background

Radical surgery is the first line treatment for localized prostate cancer (PC), however, several studies have demonstrated that surgical procedures induce tumor cell mobilization from the primary tumor into the bloodstream.

Methods

The number and temporal fluctuations of circulating tumor cells (CTC), cancer associated fibroblasts (CAF) and CTC cluster present in each blood sample was determined.

Results

The results show that both CTC and CTC cluster levels significantly increased immediately following primary tumor resection, but returned to baseline within 2 weeks post-surgery. In contrast, the CAF level decreased over time. In patients who experienced PC recurrence within months after resection, CTC, CAF, and cluster levels all increased over time. Based

SUBMITTER: Ortiz-Otero N 

PROVIDER: S-EPMC8343922 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature