Quinic acid: a potential antibiofilm agent against clinical resistant Pseudomonas aeruginosa.

ABSTRACT:

Background

The biofilm state of pathogens facilitates antimicrobial resistance which makes difficult-to-treat infections. In this regard, it has been found that the compounds screened from plant extracts represent one category of the most promising antibiofilm agents. However, the antibiofilm activities and the active ingredients of plant extracts remain largely unexplored. In this background, the study is (1) to screen out the plant extracts with antibiofilm ability against Pseudomonas aeruginosa, and (2) to identify the active ingredients in the plant extracts and elucidate the underlying mechanism of the antibiofilm activities.

Methods

Micro-broth dilution method, in vitro biofilm model, LC-MS/MS analysis and P. aeruginosa-mouse infection model were adopted to assess the

SUBMITTER: Lu L 

PROVIDER: S-EPMC8343939 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature