Adapting Rapid Diagnostic Tests to Detect Historical Dengue Virus Infections.

ABSTRACT: The only licensed dengue vaccine, Dengvaxia^®, increases risk of severe dengue when given to individuals without prior dengue virus (DENV) infection but is protective against future disease in those with prior DENV immunity. The World Health Organization has recommended using rapid diagnostic tests (RDT) to determine history of prior DENV infection and suitability for vaccination. Dengue experts recommend that these assays be highly specific (≥98%) to avoid erroneously vaccinating individuals without prior DENV infection, as well as be sensitive enough (≥95%) to detect individuals with a single prior DENV infection. We evaluated one existing and two newly developed anti-flavivirus RDTs using samples collected >6 months post-infection from individuals in non-endemic and DENV and Z

SUBMITTER: Echegaray F 

PROVIDER: S-EPMC8344047 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature