Quantitative ^[18]FDG PET asymmetry features predict long-term seizure recurrence in refractory epilepsy.

ABSTRACT:

Objective

Fluorodeoxyglucose-positron emission tomography (FDG-PET) is an established, independent, strong predictor of surgical outcome in refractory epilepsy. In this study, we explored the added value of quantitative [¹⁸F]FDG-PET features combined with clinical variables, including electroencephalography (EEG), [¹⁸F]FDG-PET, and magnetic resonance imaging (MRI) qualitative interpretations, to predict long-term seizure recurrence (mean post-op follow-up of 5.85 ± 3.77 years).

Methods

Machine learning predictive models of surgical outcome were created using a random forest classifier trained on quantitative features in 89 patients with drug-refractory temporal lobe epilepsy evaluated at the Hospital of the University of Pennsylvania epilepsy surgery pr

SUBMITTER: Kini LG 

PROVIDER: S-EPMC8344068 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature