Structural and Functional Analysis of Crucial Protein Complex in Basal Cell Skin Carcinoma via Network Construction.

ABSTRACT:

Background

The basal-cell carcinoma (BCC) as one of the most common type of skin cancers reported to have an increasing trend during past years. Molecular approaches can be useful to advance diagnosis and treatment goals in this cancer.

Materials and methods

In this sense, one of the recent popular investigations, protein-protein interaction network analysis (PPI), was applied in this study to better facilitate molecular view of BCC. Cytoscape v3.6.0 and its plugins analyzed and explored the topological and annotation features of the constructed network.

Result

Among TP53, EGFR, AKT1, ERBB2, HRAS, and CCND1 as central agents of the network, five of them were also present in the first prominent cluster of the network in which considered for further analysis. It is sugg

SUBMITTER: Zamanian Azodi M 

PROVIDER: S-EPMC8344082 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature