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(9βH)- and 17-Nor-Pimaranes from Icacina oliviformis.

ABSTRACT: Eleven pimarane-type diterpenoids were isolated from the tubers of Icacina oliviformis, including three new compounds, icacinlactone M (9), icacinlactone H 2-O-β-d-glucopyranoside (10), and icacinlactone N 3-O-β-d-glucopyranoside (11), together with an artifact of acrenol (8). Among the known structures, icacinlactone A (2), icacinlactone B (3), icacinlactone H (4), 12-hydroxyicacinlactone A (5), 14α-methoxyhumirianthol (6), and annonalide (7) are reported from I. oliviformis for the first time, whereas icacinol (1) has previously been found in this plant. Icacinol, 14α-methoxyhumirianthol, and annonalide displayed moderate cytotoxic activity in a panel of human cancer cell lines.

SUBMITTER: Sun M 

PROVIDER: S-EPMC8344086 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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(9βH)- and 17-Nor-Pimaranes from <i>Icacina oliviformis</i>.

Sun Meng M   Guo Brian B   Xu Mingming M   Zhao Ming M   Onakpa Monday M MM   Wu Zhenlong Z   Burdette Joanna E JE   Che Chun-Tao CT  

Journal of natural products 20210326 4

Eleven pimarane-type diterpenoids were isolated from the tubers of <i>Icacina oliviformis</i>, including three new compounds, icacinlactone M (<b>9</b>), icacinlactone H 2-<i>O</i>-β-d-glucopyranoside (<b>10</b>), and icacinlactone N 3-<i>O</i>-β-d-glucopyranoside (<b>11</b>), together with an artifact of acrenol (<b>8</b>). Among the known structures, icacinlactone A (<b>2</b>), icacinlactone B (<b>3</b>), icacinlactone H (<b>4</b>), 12-hydroxyicacinlactone A (<b>5</b>), 14α-methoxyhumirianthol  ...[more]

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