Compromised mechanical homeostasis in arterial aging and associated cardiovascular consequences.

ABSTRACT: Aging leads to central artery stiffening and associated hemodynamic sequelae. Because healthy arteries exhibit differential geometry, composition, and mechanical behaviors along the central vasculature, we sought to determine whether wall structure and mechanical function differ across five vascular regions-the ascending and descending thoracic aorta, suprarenal and infrarenal abdominal aorta, and common carotid artery-in 20 versus 100-week-old male wild-type mice. Notwithstanding generally consistent changes across these regions, including a marked thickening of the arterial wall, diminished in vivo axial stretch, and loss of elastic energy storage capacity, the degree of changes tended to be slightly greater in abdominal than in thoracic or carotid vessels. Likely due to the long half-li

SUBMITTER: Ferruzzi J 

PROVIDER: S-EPMC8344131 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature