Establishment and characterization of patient-derived head and neck cancer models from surgical specimens and endoscopic biopsies.

ABSTRACT:

Background

Head and neck squamous cell carcinoma (HNSCC) is heterogeneous in etiology, phenotype and biology. Patient-derived xenografts (PDX) maintain morphology and molecular profiling of the original tumors and have become a standard "Avatar" model for human cancer research. However, restricted availability of tumor samples hindered the widespread use of PDX. Most PDX-projects include only surgical specimens because reliable engraftment from biopsies is missing. Therefore, sample collection is limited and excludes recurrent and metastatic, non-resectable cancer from preclinical models as well as future personalized medicine.

Methods

This study compares the PDX-take rate, -growth, histopathology, and molecular characteristics of endoscopic specimens with surgical specimens

SUBMITTER: Struder D 

PROVIDER: S-EPMC8344210 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature