Host blood transcriptomic biomarkers of tuberculosis disease in people living with HIV: a systematic review protocol.

ABSTRACT:

Introduction

Current tuberculosis triage and predictive tools offer poor accuracy and are ineffective for detecting asymptomatic disease in people living with HIV (PLHIV). Host tuberculosis transcriptomic biomarkers hold promise for diagnosing prevalent and predicting progression to incident tuberculosis and guiding further investigation, preventive therapy and follow-up. We aim to conduct a systematic review of performance of transcriptomic signatures of tuberculosis in PLHIV.

Methods and analysis

We will search MEDLINE (PubMed), WOS Core Collection, Biological Abstracts, and SciELO Citation Index (Web of Science), Africa-Wide Information and General Science Abstracts (EBSCOhost), Scopus, and Cochrane Central Register of Controlled Trials databases for articles published in

SUBMITTER: Mendelsohn SC 

PROVIDER: S-EPMC8344288 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature