Pulmonary Microbiome of Patients Receiving Mechanical Ventilation: Changes Over Time.

ABSTRACT:

Background

Interest in the pulmonary microbiome is growing, particularly in patients undergoing mechanical ventilation.

Objectives

To explore the pulmonary microbiome over time in patients undergoing prolonged mechanical ventilation and to evaluate the effect of an oral suctioning intervention on the microbiome.

Methods

This descriptive subanalysis from a clinical trial involved a random sample of 16 participants (7 intervention, 9 control) who received mechanical ventilation for at least 5 days. Five paired oral and tracheal specimens were evaluated for each participant over time. Bacterial DNA from the paired specimens was evaluated using 16S rRNA gene sequencing. Bacterial taxonomy composition, α-diversity (Shannon index), and β-diversity (Morisita-Horn index) were

SUBMITTER: Sole ML 

PROVIDER: S-EPMC8344366 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature