Single-cell multi-omics sequencing: application trends, COVID-19, data analysis issues and prospects.

ABSTRACT: Single-cell sequencing is a biotechnology to sequence one layer of genomic information for individual cells in a tissue sample. For example, single-cell DNA sequencing is to sequence the DNA from every single cell. Increasing in complexity, single-cell multi-omics sequencing, or single-cell multimodal omics sequencing, is to profile in parallel multiple layers of omics information from a single cell. In practice, single-cell multi-omics sequencing actually detects multiple traits such as DNA, RNA, methylation information and/or protein profiles from the same cell for many individuals in a tissue sample. Multi-omics sequencing has been widely applied to systematically unravel interplay mechanisms of key components and pathways in cell. This survey overviews recent developments in single-cel

SUBMITTER: Huo L 

PROVIDER: S-EPMC8344433 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature