Aberrant expression of PROS1 correlates with human papillary thyroid cancer progression.

ABSTRACT:

Background

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer (TC). Considering the important association between cellular immunity and PTC progression, it is worth exploring the biological significance of immune-related signaling in PTC.

Methods

Several bioinformatics tools, such as R software, WEB-based Gene SeT AnaLysis Toolkit (WebGestalt), Database for Annotation, Visualization and Integrated Discovery (DAVID), Search Tool for the Retrieval of Interacting Genes (STRING) and Cytoscape were used to identify the immune-related hub genes in PTC. Furthermore, in vitro experiments were adopted to identify the proliferation and migration ability of PROS1 knockdown groups and control groups in PTC cells.

Results

The differentially e

SUBMITTER: Wang J 

PROVIDER: S-EPMC8344691 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature