Constructing and adjusting estimates for household transmission of SARS-CoV-2 from prior studies, widespread-testing and contact-tracing data.

ABSTRACT:

Background

With reduced community mobility, household infections may become increasingly important in SARS-CoV-2 transmission dynamics.

Methods

We investigate the intra-household transmission of COVID-19 through the secondary-attack rate (SAR) and household reproduction number (Rh). We estimate these using (i) data from 29 prior studies (February-August 2020), (ii) epidemiologically linked confirmed cases from Singapore (January-April 2020) and (iii) widespread-testing data from Vo' (February-March 2020). For (i), we use a Bayesian random-effects model that corrects for reverse transcription-polymerase chain reaction (RT-PCR) test sensitivity and asymptomatic cases. We investigate the robustness of Rh with respect to community transmission rates and mobility patterns.

Res

SUBMITTER: Curmei M 

PROVIDER: S-EPMC8344712 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature