Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies.

ABSTRACT: The respiratory virus responsible for coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected nearly every aspect of life worldwide, claiming the lives of over 3.9 million people globally, at the time of this publication. Neutralizing humanized nanobody (V_HH)-based antibodies (V_HH-huFc) represent a promising therapeutic intervention strategy to address the current SARS-CoV-2 pandemic and provide a powerful toolkit to address future virus outbreaks. Using a synthetic, high-diversity V_HH bacteriophage library, several potent neutralizing V_HH-huFc antibodies were identified and evaluated for their capacity to tightly bind to the SARS-CoV-2 receptor-binding domain, to prevent binding of SARS-CoV

SUBMITTER: Stefan MA 

PROVIDER: S-EPMC8344751 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature