Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis.

ABSTRACT: Metastasis is the leading cause of cancer-related deaths, and greater knowledge of the metastatic microenvironment is necessary to effectively target this process. Microenvironmental changes occur at distant sites prior to clinically detectable metastatic disease; however, the key niche regulatory signals during metastatic progression remain poorly characterized. Here, we identify a core immune suppression gene signature in pre-metastatic niche formation that is expressed predominantly by myeloid cells. We target this immune suppression program by utilizing genetically engineered myeloid cells (GEMys) to deliver IL-12 to modulate the metastatic microenvironment. Our data demonstrate that IL12-GEMy treatment reverses immune suppression in the pre-metastatic niche by activating antigen prese

SUBMITTER: Kaczanowska S 

PROVIDER: S-EPMC8344805 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature