Ontology highlight
ABSTRACT:
SUBMITTER: Gutierrez-Gutierrez O
PROVIDER: S-EPMC8344900 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Gutiérrez-Gutiérrez Óscar Ó Felix Daniel A DA Salvetti Alessandra A Amro Elias M EM Thems Anne A Pietsch Stefan S Koeberle Andreas A Rudolph K Lenhard KL González-Estévez Cristina C
EMBO reports 20210630 8
Planarians are able to stand long periods of starvation by maintaining adult stem cell pools and regenerative capacity. The molecular pathways that are needed for the maintenance of regeneration during starvation are not known. Here, we show that down-regulation of chaperonin TRiC/CCT subunits abrogates the regeneration capacity of planarians during starvation, but TRiC/CCT subunits are dispensable for regeneration in fed planarians. Under starvation, they are required to maintain mitotic fideli ...[more]