β-Glucosylceramide From Allergic Mothers Enhances Offspring Responsiveness to Allergen.

ABSTRACT: In animals and humans, offspring of allergic mothers have increased responsiveness to allergen and the allergen-specificity of the offspring can be different than that of the mother. In our preclinical models, the mother's allergic responses influence development of the fetus and offspring by elevating numbers of cells in dendritic cell subsets. A major question is the identity of maternal factors of allergic mothers that alter offspring development of responsiveness to allergen. Lipids are altered during allergic responses and lipids are transported to the fetus for growth and formation of fetal membranes. We hypothesized that pro-inflammatory lipids, that are elevated in allergic mothers, are transported to the fetus and regulate fetal immune development. We demonstrate in this report th

SUBMITTER: Walker MT 

PROVIDER: S-EPMC8345025 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature