Lobular Breast Cancer: Histomorphology and Different Concepts of a Special Spectrum of Tumors.

ABSTRACT: Invasive lobular breast cancer (ILC) is the most common special histological type of breast cancer (BC). This review recapitulates developments in the histomorphologic assessment of ILC from its beginnings with the seminal work of Foote and Stewart, which was published in 1941, until today. We discuss different concepts of ILC and their implications. These concepts include (i) BC arising from mammary lobules, (ii) BC growing in dissociated cells and single files, and (iii) BC defined as a morpho-molecular spectrum of tumors with distinct histological and molecular characteristics related to impaired cell adhesion. This review also provides a comprehensive overview of ILC variants, their histomorphology, and differential diagnosis. Furthermore, this review highlights recent advances which h

SUBMITTER: Christgen M 

PROVIDER: S-EPMC8345067 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature