From Micro to Long: Non-Coding RNAs in Tamoxifen Resistance of Breast Cancer Cells.

ABSTRACT: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality among women. Two thirds of patients are classified as hormone receptor positive, based on expression of estrogen receptor alpha (ERα), the main driver of breast cancer cell proliferation, and/or progesterone receptor, which is regulated by ERα. Despite presenting the best prognosis, these tumors can recur when patients acquire resistance to treatment by aromatase inhibitors or antiestrogen such as tamoxifen (Tam). The mechanisms that are involved in Tam resistance are complex and involve multiple signaling pathways. Recently, roles for microRNAs and lncRNAs in controlling ER expression and/or tamoxifen action have been described, but the underlying mechanisms are still little explored. In this rev

SUBMITTER: Barazetti JF 

PROVIDER: S-EPMC8345104 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature